UMBC ebiquity
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Domain-based computational approaches to understand the molecular basis of diseases
September 5, 2008
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Protein domains, or domains, are the evolutionary, structural and functional units of the proteins. Despite the obvious relevance of domains to understanding biological process at the molecular level, most high-throughput experimental data relating molecular information to biological process, including diseases, is only analyzed at the gene or protein level. I will introduce a new approach, the protein domain profiling, to analyze clinical data derived from microarray and other experimental high-throughput technology. I will show how to use this approach to integrate mutational, alternative splicing and other molecular events with protein interaction and gene expression. In addition, I will introduce HPDD, a database of human protein domains available at http://bioinf.umbc.edu/hpdd which provides a unique resource for study of protein domains and human diseases.
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