FALCON: Zero in on the Native Protein Structure
by Ming Li
Friday, February 1, 2008, 15:30pm - Friday, February 1, 2008, 16:30pm
We believe the protein structure prediction problem will only be solved by a simple computational model. We wish to find a single and simple mathematical model that encompasses all of above paradigms and that takes a sequence and converges to a near-native protein structure. We propose such a theory, integrating ideas from fragment assembly, hidden Markov model sampling, and Ramachandran basins. Our initial implementation, FALCON, of this theory converges to near-native structures on short benchmark protein sequences, and produces significantly better protein structures than the best programs in this field.
Joint work with: Shuaicheng Li, Dongbo Bu, and Jinbo Xu.